Advise patients to prevent partaking in dangerous tasks demanding mental alertness and motor coordination following ingestion of promethazine HCl and codeine phosphate oral Resolution. Keep away from concurrent use of promethazine HCl and codeine phosphate oral Answer with Alcoholic beverages or other central anxious method depressants simply because supplemental impairment of central nervous process functionality might come about [see Warnings and Safeguards (five.10)].

Greater force with your head (amplified intracranial force). Keep away from using Promethazine Hydrochloride and Codeine Phosphate Oral Solution When you have a head harm or are already advised that you have variations inside the tissue of your brain (brain lesions) or amplified tension with your head.

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Bronchial asthma and also other Pulmonary Illness The usage of promethazine HCl and codeine phosphate oral Option in people with acute or significant bronchial bronchial asthma within an unmonitored setting or in the absence of resuscitative gear is contraindicated [see Contraindications (4)]. Opioid analgesics and antitussives, including codeine, among the list of Energetic ingredients in promethazine HCl and codeine phosphate oral Answer, should not be used in clients with acute febrile sickness connected with effective cough or in patients with Long-term respiratory disorder the place interference with ability to distinct the tracheobronchial tree of secretions might have a deleterious effect on the patient’s respiratory function.

For Expecting mice and rats that been given promethazine at doses 0.two and three to 6 periods the MRHD, through various intervals of gestation, there have been results of increased fetal resorptions and skeletal fragility, reduced pup pounds, and developmental delays of pups (see Knowledge). Based upon the animal info, advise pregnant Women of all ages of your potential possibility to some fetus.

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Promethazine has an elimination fifty percent-lifetime of 10 to14 hours, with excretion of metabolites showing up inside the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine would be the predominant metabolites showing up during the urine.

Use warning when considering the use of promethazine HCl and codeine phosphate oral Answer in individuals sixty five several years of age or more mature.

All facts presented Here's not meant in its place for or alternative to details from health and fitness treatment practitioners. Please consult your well being treatment professional about likely interactions or other feasible issues prior to applying any item. The Federal Meals, check here Drug, and Cosmetic Act require this see.

Codeine was not mutagenic from the in vitro bacterial reverse mutation assay or clastogenic within the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.

Stay away from using promethazine HCl and codeine phosphate oral Alternative in sufferers who will be using inhibitors of CYP2D6.

Acute or serious bronchial bronchial asthma in an unmonitored location or in absence of resuscitative products. (4)

Postmarketing scenarios of respiratory melancholy, such as fatalities happen to be claimed with utilization of promethazine in pediatric patients.